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1

Development of Novel Bisphosphonate Prodrugs of Doxorubicin for Targeting Bone Metastases That Are Cleaved pH Dependently or by Cathepsin B: Synthesis, Cleavage Properties, and Binding Properties to Hydroxyapatite As Well As Bone Matrix

Hochdörffer, Katrin, Abu Ajaj, Khalid, Schäfer-Obodozie, Cynthia, Kratz, Felix

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 625 KB

english, 2012

2

Development of Protein-Binding Bifunctional Linkers for a New Generation of Dual-Acting Prodrugs

Ajaj, Khalid Abu, Biniossek, Martin L., Kratz, Felix

Journal:

Bioconjugate Chemistry

Year:

2009

Language:

english

File:

PDF, 228 KB

english, 2009

3

Development of dual-acting prodrugs for circumventing multidrug resistance

Khalid Abu Ajaj, Felix Kratz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 234 KB

english, 2009

4

Synthesis of a complex disaccharide precursor of phosphonate analogues of the antibiotic moenomycin A12

Khalid Abu Ajaj, Lothar Hennig, Matthias Findeisen, Sabine Giesa, Dietrich Müller, Peter Welzel

Journal:

Year:

2002

Language:

english

File:

PDF, 333 KB

english, 2002

5

In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B

Khalid Abu Ajaj, Ralph Graeser, Iduna Fichtner, Felix Kratz

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 356 KB

english, 2009

6

A Toll-like receptor 2–integrin β3 complex senses bacterial lipopeptides via vitronectin

Gerold, Gisa, Ajaj, Khalid Abu, Bienert, Michael, Laws, Hans-Jürgen, Zychlinsky, Arturo, de Diego, Juana L

Journal:

Nature Immunology

Year:

2008

Language:

english

File:

PDF, 464 KB

english, 2008

7

Zosuquidar and an albumin-binding prodrug of zosuquidar reverse multidrug resistance in breast cancer cells of doxorubicin and an albumin-binding prodrug of doxorubicin

Khalid Abu Ajaj, Ralph Graeser, Felix Kratz

Journal:

Breast Cancer Research and Treatment

Year:

2012

Language:

english

File:

PDF, 865 KB

english, 2012

8

Dipalmitoylation of a cellular uptake-mediating apolipoprotein E-derived peptide as a promising modification for stable anchorage in liposomal drug carriers

Ines Sauer, Heike Nikolenko, Sandro Keller, Khalid Abu Ajaj, Michael Bienert, Margitta Dathe

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2006

Language:

english

File:

PDF, 427 KB

english, 2006

9

Development of a novel prodrug of paclitaxel that is cleaved by prostate-specific antigen: An in vitro and in vivo evaluation study

Bakheet Elsadek, Ralph Graeser, Norbert Esser, Cynthia Schäfer-Obodozie, Khalid Abu Ajaj, Clemens Unger, André Warnecke, Tahia Saleem, Nagla El-Melegy, Hafez Madkor, Felix Kratz

Journal:

European Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 747 KB

english, 2010

10

Comparative evaluation of the biological properties of reducible and acid-sensitive folate prodrugs of a highly potent doxorubicin derivative

Khalid Abu Ajaj, Naser El-Abadla, Pia Welker, Samar Azab, Reiner Zeisig, Iduna Fichtner, Felix Kratz

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

11

SYNTHESIS OF α-THIOPHENE OLIGOMERS VIA ORGANOTIN COMPOUNDS

Kamal, Marwan R., Al-taweel, Samir A., El-abadelah, Mustafa M., Abu Ajaj, Khalid M.

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1997

Language:

english

File:

PDF, 464 KB

english, 1997

12

Anticancer carrier-linked prodrugs in clinical trials

Kratz, Felix, Abu Ajaj, Khalid, Warnecke, André

Journal:

Expert Opinion on Investigational Drugs

Year:

2007

Language:

english

File:

PDF, 319 KB

english, 2007

13

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Pes, Lara, Koester, Stephan David, Magnusson, Johannes Pall, Chercheja, Serghei, Medda, Federico, Ajaj, Khalid Abu, Rognan, Didier, Daum, Steffen, Nollmann, Friederike Inga, Fernandez, Javier Garcia,

Journal:

Journal of Controlled Release

Year:

2019

Language:

english

File:

PDF, 1.46 MB

english, 2019